My answers, please read what is written in the thread here Voyager and the others there are a lot of answer on some common questions foro who coming from another astro application:
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You can change the sequence when you want, sequence running a shadow copy of sequence. If you want to apply changing to a running sequence you must stop the sequence and restart, you have options on how to restart ( https://voyager.tourstar.net/index.php?title=OnTheFly#Running_a_Sequence ) but sequence will be restarted from slot 1 … no memory and was done previously. This options are also on the dragscript section if you use DragScript. For the DragScript the sequence not actual running can be changed without reload dragscript (sequence will be loaded just at running from disk). During sequence you can pause and do action like pointing focus, flat and other and restart after a precise pointing the suspended sequence but the sequence settings will be not reloaded. You can inject a focus during sequence running from here https://voyager.tourstar.net/index.php?title=Main_Window#Monitor
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Stretching in FIT Viewer is exactly like PixInsight auto screen transfer function so its really strong. If you want you can folllow what @yzhzhang wrote, cursor clip strech, cursor bkg change starting level of background for stretch (this is not cursor like usual but cursor changing directly parameters of PixInsight stretch function).
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i think you can get satisfation and solution using web dashboard. under the original GUI this controls are fixed, sorry.
All the best
Leonardo